Wei-Yu Lin, Yanju Wang, Shutao Wang, and Hsian-Rong Tseng
Department of Molecular and Medical Pharmacology, Crump institute for Molecular Imaging (CIMI),
Institute for Molecular Medicine (IMED), California NanoSystems Institute (CNSI), University of
California, Los Angeles, Los Angeles, CA, USA


Microfluidic reactors exhibit intrinsic advantages of reduced chemical consumption, safety, high surface-area-to-volume ratios, and improved control over mass and heat transfer superior to the macroscopic reaction setting. In contract to a continuous-flow microfluidic system composed of only a microchannel network, an integrated microfluidic system represents a scalable integration of a microchannel network with functional microfluidic modules, thus enabling the execution and automation of complicated chemical reactions in a single device. In this review, we summarize recent progresses on the development of integrated microfluidics-based chemical reactors for (i) parallel screening of in situ click chemistry libraries, (ii) multistep synthesis of radiolabeled imaging probes for positron emission tomography (PET), (iii) sequential preparation of individually addressable conducting polymer nanowire (CPNW), and (iv) solid-phase synthesis of DNA oligonucleotides.  These proof-of-principle demonstrations validate the feasibility and set a solid foundation for exploring a broad application of the integrated microfluidic system.


Integrated microfluidics; Chemical screening, In situ click chemistry; Sequential synthesis, Positron emission tomography probes; Oligonucleotide synthesis; Conducting polymer nanowires

Published in final edited form as: Nano Today. 2009 December ; 4(6): 470–481. doi:10.1016/j.nantod.2009.10.007.